The role of β-adrenoceptor signaling in skeletal muscle: Therapeutic implications for muscle wasting disorders

R Koopman; JG Ryall; JE Church; GS Lynch

Journal article

The role of β-adrenoceptor signaling in skeletal muscle: Therapeutic implications for muscle wasting disorders

R Koopman, JG Ryall, JE Church, GS Lynch

Current Opinion in Clinical Nutrition and Metabolic Care | Published : 2009

DOI: 10.1097/MCO.0b013e3283318a25

Abstract

PURPOSE OF REVIEW: The β-adrenergic signaling pathway represents a novel therapeutic target for skeletal muscle wasting disorders due to its roles in regulating protein synthesis and degradation. β-Adrenoceptor agonists (β-agonists) have therapeutic potential for attenuating muscle wasting associated with sarcopenia (age-related muscle wasting), cancer cachexia, sepsis, disuse, burns, HIV-AIDS, chronic kidney or heart failure, and neuromuscular diseases such as the muscular dystrophies. This review describes the role of β-adrenergic signaling in the mechanisms controlling muscle wasting due to its effects on protein synthesis, protein degradation, and muscle fiber phenotype. RECENT FINDINGS:..

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University of Melbourne Researchers

Gordon Lynch Author

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Grants

Awarded by Australian Research Council Discovery-Project

Awarded by National Health and Medical Research Council of Australia

Awarded by Australian Research Council

Funding Acknowledgements

The funding for this research has been provided by generous grants from the Australian Research Council Discovery-Project funding scheme (DP0665071, DP0772781), the National Health and Medical Research Council of Australia (454561, 509313), the Muscular Dystrophy Association (USA, 4167), Association Francaise Contre les Myopathies (France, 13572), the Rebecca Cooper Medical Research Foundation, and Pfizer Inc. (USA). R.K. is supported by a Rubicon Research Fellowship from the Netherlands Organization for Scientific Research (NWO). J.G.R. is supported by a Biomedical Overseas Research Fellowship from the National Health and Medical Research Council of Australia (520034).